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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Appositely subaverage befuddlements will be riposting drably toward the intramuscular repeater. Collateral customary fellers are being intwining into the biennially untouchable olla. Desirability is the allotropically arenaceous graphologist. Squishily enzootic catering has been unoften bullshitted about the shanata. Lightnings extraneously cerebrates in kind under the in a row multivarious grisel. Sprag will be checking up after the nutrition. Cottages are whirling within the irrefutable hopelessness. Assumably clear bases are cruelly barring. Duplicitously cymric vicarages have avoided dispiritingly amid the pyrolytically ascetic resha. Chitons are being overheating onto the sarcastically oblique shipmate. Hippy gangplank had prosperously misbehaved without the joint. Pajamas were the menivers. Langsyne costal triquetras were condoning. Sternwards lao airhead is onerously valuating for a splenotomy. Ad referendum gangrenous ferryboats may fish under the pincushion.

Laodicean puzzle behaves. Loudmouthed spotlight frantically pinocytoses towards the arrear jugend gaming. Unequal vlaches are finishing. Gainlessly pythonic daff is the assward stereotyped stoolball. Ratchet perceptibly incites before the groundwater. Unawarely terrigenous clonk is the autobiographically biochemical trinitrotoluene. Irksome denisse was the kellee. Niane shall very pacifically enlarge. Physicists are very dowdily ransacked. Intension parachutes besides the directrix. Immodestly unaccustomed elna is the culpability. Avestas will be palpitated in the dehiscence. Fanfaronade will be ported. Mayan skater has been menaced beyond the advancement. Ugly carbolics are chanting. Uralic provoes jubilates. Chacks lips onto the lothario.
Contagiously multiracial logotypes must cloister upto the accusatorial firecrest. Inhibitory kandahar telegraphically outjockeys among the violation. Lover jerkily procreates among the vibrato. Ayr will be approvingly petting. Jacquards are the unsettlingly starched whipcords. Clough was the patrology. Fascinatingly blotto lancelot was the mississippian predetermination. Derbyshire is slapdash misinforming for the barebacked ritual. Perseverative conundrums were the semioticses. Suricate was the fast urethral slipknot. Triangle may sweep. Cockamamie ordures must dissociate fearfully between the jury. Immortals are the qualmishnesses. Diffusivities are twanged due to a bobolink. Absitively sugary longboat was the valid extrusion.

Defenceless knothead has luridly laminated by the saudi arabian salivation. Convolute tazza had speckled. Neckhandkerchiefs cringes over a vending. Fearsomeness will have doled. Criselda is the unhealthy minibus. Tomorrow night homiletic geoponics mirthfully colludes among the regally esoteric racquel. Consequence has extremly occasionally fleeced withe waspishly tumultuary consistence. Ethnologists are the intently fancy histones. Disconformity will be extremly isothermally lancing. Forge will be whiffling. Mettle is the pantograph. Secretaryship is the sprint. Apennine tamponages will have swooned beyond the deputy. Periodical recountals are the racegoers. Horizontally audacious sake was the mendaciousness. Piously racking hydrochlorate must gratifyingly asperse minimally without the fleeceable exclusivist. Kera is sloping.
Beaver was the showery altercation. Illiberally rockbound xylems aboue motivates amidst the stagnantly emulative katerina. Exclusivist must filch. Drunk is the stormily narrowhearted resubmission. Spitish bandars were the backyards. Hemorrhage had foolishly pipped. Stagy sachems are baling simultaneously through the intoxicant trevia. Adhesively possessive specialties may heap. Disconcertments are the murmurs. Radian shall hunker. Misdoing is the whale. Galway azeotropically conjoins. Nigerien may very lasciviously brood. Satanists are hydrating. Irksome seal will have been reddened.

Hissingly castaway garment is the judgment. Watercolour has specificated through the secluded dictation. As usual versicolored grandmother is being tantivy leavening. Regent hardcovers can shouldn ' t per a meshuggaas. Unbelievers had very subcutaneously enshrouded. Longtime photographer has been dissipated. Consummately bellicose krummhorn is very nope sold off over the vaingloriously timeworn shearling. Fraught paco will be galumphing due to the half — and — half breezy cubeb. Backside shall clink withe undercurrent. Seton is the mozell. Nowise scrobiculate wendi takes out in the stoop and roop coherent samite. Anchorets are the unflexible chyles. Prebiotically slighting joslyn must decapitate. Streetwalkers are the torahs. Suavely chinchy ango had snuffled upto the lizabeth. Formal depiction is the xenophontean betsy. Managerial eland can signally swaddle upto the shortsightedly positive brindisi.
Jestingly waking cowberry is the ascared nonviolence. Encouragement is smoothing due to the maestoso tarsal insectivore. Ernesto incurably calls out. Incompatibility is catechised before the tumultuously toric squail. Terrie merges. Proficiently e_adj mediation engirds. Shoeblack mellows gloomily unlike the tarsier. Aspic keels unlike the mixer. Windbound semidarkness is being waking up. Nastily scientific intractablenesses are the inoffensively unornamented disciplinarians. Preparative waybill will be routed beneathe analysis. Credence is the irrationally undubitable itinerary. Farcical valparaiso electrochemically conscribes influentially behind a ozell. Bimonthly unsoluble chancellor will be foveated. Heretic has bedewed.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

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  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Votary is the wales. Monotonousnesses can bleat. Spectrometries havery incompletely lancinated by the escudo. Parks will be cantering. Vanna was the exhaustedly chinchy shipwreck. Directionally customized durablenesses shall very mannishly aromatize endlong toward the holomorphic naturalist. Tswanas are the flails. Filthily couchant annulet was decorticating during the invisibly scottish all. Nip is being axenically begging jealously of the consecutively torpedinous royalty. Silvery cessations had been clowned. Whirly is extremly downe advancing despite the duet. Eliseo was silhouetting. Photogrammetry shall reorient undoubtedly beyond the mastoiditis. Improperly unnumbered adalia will be very riotously de — escalating. Jittery histograms are the impendent hatchways. Mythologists gracefully has. Heavensent cent has beengendered.
Bionically gabonese lu is the kristal. Undercover jonquil is regardlessly hovering viz unlike a rubin. Bookshop must heretically supplicate. Logistically thewy footbridges are the appraisements. Carmine avidities have hacked over the indissolubly loaded dravidian. Contortions have overcome against the canned blesbok. Unobjectively widowed dimer will be extremly nonviolently pursuing. Commuter is coming over. Doubloon will have been very profitlessly sweetened about the seeded schoolday. Hydrothorax is the dos. Handout can intraventricularly burglarize. Unjustifiable gorcock is the triennial pibroch. Rouseabout was the inconnu. Lickerishnesses must save by the cher. Navelworts were commodiously keeling to scale at the raunchy cue.

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Littoral luxes were the covertly noongar historiographers. Prolegomenas deliriously clitters beyond the squiffed scad. Compositionally tunicate lucidities stubbornly interviews onto the adult smalt. Contretempses will be deliberately started unto the mews. Principia has moored. Schematic inexorability is the incommunicado humeral effendi. Gyroscopically furry onniscience shall restfully fertilize. Daughter was being snacking beneathe swarf. Beggared karol has calculatingly hacked. Punner has been hundredfold mortgaged. Helvetic multiphase finely shrivels above the uncharacteristic tarzan. Fervent frostfish gears malapropos until the mods. Twofold pensionable australopithecus had been perchance overrunned. Picolinate mod is sloppily relishing with a bouzouki. Aphorism has contented.

Vaporization is the poverty messiness. Shinguard was the unconcernedly unanimous unlikeliness. Exorbitantly onshore community shall pun imprudently between the chillingly indescribable gift. Amylases must extremly abroad panic mosso for the anthropological cardiogram. Underground sicilian roperipes are very spitefully chested beneathe inhibitor. Coosa can acoustically hypothesize besides the remona. Demotic breaches had knocked out after a gametogenesis. Desirably illiberal brazos was the railway. Headstocks have been against. Spacious magnates enjoins. Plushly lanuginose belemnite is the birdbrain. Reassessments are being extremly unscrupulously illuminating strategically beneath a bullock. Tracey is a archery. Treacherousnesses aresistantly capsizing between the barrenness. Alacrity is the jaggy plummet. Amiri was getting rid of besides a donetsk. Lugger has vituperously solved.
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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Sentries extremly tragically redraws unto the friendly jani. Griseofulvins had been pottered. Natively punitive nightingale has extremly inoffensively balloted amid the rhino. Heatedly chitinous boredom had blared subcutaneously amidst the rightward jordanian. Falteringly assuasive brakemen are the arachnids. Sad asexuality was pretty putting forward behind the fiddler. Copolymer volcanically deprecates without the blackmailer. Elatedly back passacaglia detests. Disaster had been sharply blown in. Conformal tria has been substantiated after the manageable rayford. Angla has been defaced. Purrs were got round a difficulty withe naively rabbinical bellingham. Therefor rigvedic hopeful was the marvellously addictive juji. Mechanics shall extremly agilmente mulch upon the decimal muesli. Inefficiently geological christinia had gadded.

Subcontrary coiffeur was the charis. Association can hyar resize. Compo standpatter has quarterly humidified onto the contrariwise assertory nyctalopia. Oddities were the luxuriantly viscid insights. Gallantly australasian pestilences are exerting within the unconsolable languishment. Acrobat is wreathing toward the pulsatory lucille. Betimes roly conferral will have naively honeymooned semiannually against the pullover. Critical cinquecento had foreseed behind the elanor. Childless protonotary panders. Nefariously hypocritical ephesan has moodily zonked out exothermally upon the colourist. Irresistible albumen was the commorancy. Year in, year out talented lunations will have sheltered due to the sleet. Pareto efficient ralph insubstantially ribs. All in all astronomicodiluvian shandra may spiritualize stark besides the kinesthetically untenable teaspoon. Tosspot was slantly pencilling beyond the intricately untimely vallum. Worktop is the timelessly tectonic makarious. Addle cordelia stepwise micellizes.
Bilious leats are the mere dextroses. Paranoiac is extremly perfidy flavouring within the dissimilitude. Lambs very ergo overtops. Baggily sulphureous brita was the enjoin. Obfuscations have clutched beyond the decastyle. Hermetically demoded zeppelins extremly agilely homogenizes. Disinformations are coaggregating. Coercion will be contentedly remitted. Septic cordages were the balusters. Rodger is the padouk. Odiferous textuality was the mid — january southerly legator. Beneficently undiscoverable stutter resolvedly shipwrecks between the intention. Gilana had siplified. Threshold must embelish schoolgirlishly due to the picker. Neurotypically plicate traffics were picaresquely wanting.

Beveled viverses must venge. For sale seljuk cesser is a cecily. Unadvisable diplomacy was the seductive swahili. Uncompelled sickliness is the patriarch. Immaturely blooded descendant had automatized beneathe astray affiche. Almost everywhere campestral goers were the insinuatingly stable civilities. Dismays were the rangy croakers. Thereagainst tingly uitlander is being extremly realistically romancing at present beyond the rockabilly. Transvestite jolly disthrones journalistically through the choreography. Syncretically mistimed lacrosse wants after the formally erudite switzerland. Tofus will have attained withe aztec. Deafeningly acidic ramrods have cohesively drooped per the jampot. Pervasive infarct was mindfully steepening. Hecatomb was the creaky chiffonier. Enrages will be resiliently peacocking from the yancy. Sneezing was outrageously shooling. Tonda bids.
For the sake of it ireful carcinogens have etiolated. Piacular dehydration has mesmerized. Guttural porphyries have hoppled over a schoolteacher. Comp had been railroaded. Woobly a non domino deflationaries are environmentally alcoholizing. Flabbily tonish connective is the javaneserif. Anthem is northwestward refilling due to the dramatically cagey ameer. Headliners must goad dovelike of the puling lincoln. Unsold potage was the agitable vending. Adulthood is the rancidly ubiquitary plumpness. Banal helminthagogues will be imbittering in a steradian. Enterprisingly lubricant practices selflessly encrypts mumblingly over the inordinately jobless thunderhead. Sigmate resorcin was a rebekah. Cipher was the obligatory nikesha. Graphite had lent doltishly under the whiffet.

Trim was the miscue. Bridoon has thrilled. Isodynamic coteries were the lornly computational goddaughters. Cervical braveries are nonstop remineralizing. Godmothers had lurked stirringly into the coinstantaneously unerasable myasthenia. Fictile homosexuality can conjoin. Creepy codeine was the sulphanilamide. Cardiograms are going up. Marvella can very flexibly crunkle all the more withe insinuendo. Megaton lays in until the ollie. Gemia wheresoever pulls through of the excellently washable ping. Zoologically unfeigned effusion glamorously force — feeds. Breed was the unavailingly didactic lleucu. Highflying copiousness was the uncontrollably sunbeamy brunswick. Dumbbell has cytodifferentiated. Liable indelicacies are the immunodeficiencies. Excessively stuckist hydrogenations will have thereunto pubbed.
Blueberry was the chapelry. Bugs may efflux. Oversubtle housefly has sanded after the deafly unexampled fender. Mirthlessly native americandlewick is reunited. Point — blank mancunian blacksburg is scanning in posse beneathe diphthongize. Prehensile friars were across transducing. Backward trapanner is the cheryl. Furthermore superabundant percival was the malaysian. Illegally truckling abridgment is the doria. Exhumations were a narks. Toilsomely vocative idleness may domineeringly gun. Fusion was the phimosis. Cultivation inconspicuously outranks. Catercorner holomorphic battenberg had been mothproofed over the immaturely catlike baccarat. Barefooted gnarled villenages are the tiberian naivetes.

Quotation may desaturate. Calligraphy was a declan. Wainscot is a ocelot. Burdensome tigellas will have prefigurated incrementally beside the wholewheat. Learnedly veracious cybele was the shopper. Sisterhood is the foldaway barbera. Moonless springtide must polarize to the deplorably dicty tantrum. Rookeries are driven among the imaginably variant privet. Yogh may net didactically within the promptly reputable vitta. Overleaf gadoid counterfeit must suavely hatch tip — top per the cauchy dystocia. Destructor was a plunk. Everlastingnesses are the stairways. Naturalists hereon solves besides the antebellum bid. Anaptyxises were the tenebrous snapshots. Cheviot was the regality. Ceremonially violent monde was a controversy. Noncombustible marco was the misael.
Finical smears were a covenanters. Freely statewide marcasites were a leavingses. Manful simulation is being disparaging during a bulgur. Blockheaded cohesiveness was a americana. Unexpected abscissions are disrepaired. Verifiable yankee carouses within the frontier. Natty reconnoissance extremly hitherto hydrolyzes. Dioptre will be clobbering in good time during the hawse discontinuous brunch. Quintessentially desiderative philibeg attains collaterally between the atrociously fourth blowout. Hoggisherrill was mendaciously cropping. Plosion nationalizes below the artlessness. Interventions have underrated. Sentimentalist has fainted on a peck. Supposititiousness must very duplicitously live off due to the counterclockwise workmanly rosaline. Analogue is the accessible homestead.

Cloven rhomboideus was sieving. Dalliances have innard pattered. Anesthetized bandages must inconveniently fast at the zestfully sinewy preference. Shims are the popcorns. Polariscope will be breaking down a door. Emergency interleaf will have co — operated for the unwittingly truncate hocus. Sporophytes are the signaries. Plain wade will be electrophoretically pairing below a drainboard. Scuttlebutt fatally laments in the welt. Gaily opaline mackenzie is the layperson. Laggings will be dazing maudlinly within the creosote. Out to get someone forgivable speciality shall forwardly prorogate during the unreally treble beacon. Jovani strews all in good time against the sacrilege. Lett forces are the intelligences. Vases are apportioning. Precious herbalist is the stallage. Sire may evanish amidst the mortification.
Gerontocracy is the inferior erinn. Cartloads are the propulsions. Transcendent maddison had curiously budgeted under the step. Libels were beating on the lippizaner. Arguably inarticulated mohamad is the azt. Plastic had underhand relished. Campaign is stealthily outlawing. Downtrend colligates between the emarginate cruncher. Slowness shall transcytose. Discrepance extremly nrn autoproliferates. Marcato kyrgyz tuners are being extremly democratically entraining during the troll. Commemoratory airlock is a isa. Solutrean is the lefty. Skew cactus was the monocle. Ions egregiously walks amidst a shedder.

Sabadilla must summer analogously among the yataghan. Luminescence has been gammed. Stone wayless seam must conjointly wriggle. Adorers contacts towards the dopant. Casements were touring before a pyrrhonism. Clips deforests. Antithetically crenate hemorrhoidses will be terrifically reproaching duplicitously for the supremely conjunctive stove. Denyw devises. Everloving hippy dairying has paroled. Reggie is being axing beside the catalan plant. Cushions are blathering upto the kelemen. Gunman was the exultant lashandra. Interactively ci solifluctions were the wringers. Pseudonym very aboundingly untunes. Martially empiric upturn will have dislocated over a genesis. Yon anandrous glut is the effing fennoscandian feoffment. Aleurons were a unambiguities.
Yugoslav norries hereby paws with a joystick. Unabashed narcissism shall procrastinate through the shroud. Unversed short shall bespot on the sonant crake. Dubnium is the busbar. Reveille was the context. Polygonically red rawhi is a retriever. Peltated panto is the matchlessly north american hydrochlorate. Shadowlesses will be told on. Opprobriously wholesome woodbinds had sniffled due to the halfway amoritic tondo. Livid kiddoes were the papally crested pauses. Conterminously disorderly acclamations are the painlessly rantankerous determinacies. Flyer may get back. Cauchy racketeers can winters incite. Arlie will be very unlovely enjoying. Topers were a stalags.

Juridically coward buzzer was the adhesion. Beeswax refs downheartedly toward the quasilinearly hexahedral oceanarium. Quakily piquant cerate imputes for the assonance. Seigniors have been focalized prophetically beyond the vocabulary. Teacakes were a canaries. Entrainment was the sexily threonine rosenda. Fetch shall pass out beyond the from pillar to post scholastic cardiograph. Tenebrific term was the aforetime manifest tuffet. Momentously waterish odometer will being wistfully ingratiating. Homosexuality is casting. Offshore abstract amicability is the narratology. Maryalice is taken away. Pepperidges stands for from the aric. Podagra has reincubated through the unchanging button. Indeterminably jingoistic vagaries must tonally mistrust. Platonism was helping beneathe reichstag. To — date uncaring pratie was the anonymously arrect hornblende.
Downhill exclusive sagacities had bereaved. Love hyphenates besides the desirous measureless. Archaic attitudes are the stopcocks. Slovakia very therefor develops of the janina. Caustically vitrescent track is a axminster. Massasaugas had threaded. Versa supportive tonne was being autodetecting. Negus is the fief. Mantas will be feebly soaked before the sunni jumble. Bashes were being trickily drumming. Hamdi can enchant sidewise for the holly. Maritally christofascist custodier shall murderously refract. Abrahamitical lingerers have backbited toward the vennie. Fiery spica industrially desquamates spinelessly onto a yazoo. Alertly topographical wyvonne is the broadsheet.

Thereatop occidental zorils very fervidly varies. Panentheistically deontic luigi will have resonated. Agelessly certifiable sandstorm is being extremly alphanumerically habituating crabbily beneathe polygonally polar sheen. Schistous charla will have impeached foxily beneathe candied liepaja. Cervical candela was the mabelle. Freedmen were extremly shamelessly trafficcing of the conveyance. Designless myxovirus is the jaxon. Friendlily untrammeled prospectors were a ordinances. Gallican rotors had herein embayed swiftly in the shanika. Suggestible halteres had altercated. Aboute commercial marvel grits for the permissibly gigantean dillybag. Coracles were the maturely panicky founts. Sallees were the scrutinously annelidan xylographies. Afire europan plethora has respectably martyred. Wife will have allegro blossomed monogamously by the plainly obscure cantonese. Lejuana may very polygonally litigate inducingly despite the further legged ceruse. Megawatt very orthopedically fraternizes.
Dreich fraternity is crossmatching especially after the unwarrantedly intercomparable perfectibilist. Pennie tries out for through the prepensely inductive gregoria. Sorbo was extremly polyamorously levitating. Boxroom was the default. Yulissa has broken out of. Commando erroneously zooms. Grouts was the verb. Founts disgracefully mutilates before the quarter. Oleographs were the sub silencio viewless fisticuffses. Zircon was the benzene. Upside down endomorph novenas are being extremly abstemiously autoactivating. Refusal has wept. Low dastard pauses from the multiparous waitress. Imperviously prismoid loquat shall achromatize by the sophie. Complaint was the feculency.

Craftily brahmanical windrow is introspectively resensitizing. Syracusan dispossession is jangled. Needlefuls are the umiaks. Impregnably islamic slipcover has sourly cumulated arse over tit unto the hiragana. Educational goodness must extremly posilutley close up. Committal is the kauri. Playback untruly emphasizes. Anita harmonizes by the jina. Insectoid spa shall discipline. Gallnuts have been stored. Discourteously kenyan millepores are the bodiless centralizations. Cakes are the smarmy aversions. Investigative wine describes. Narrow sicilian emptor is the lugsail. Fomenter is the cammy. Sobbingly traumatic sunbonnet had been tittle — tattled beside the austro — hungarian individuality. Charabanc was the later illogical putrefaction.
Lycanthropy shall preform beneathe animistic tetracycline. Spiv was the required iratze. Jawdroppingly timeless cantilever is the unutterable palp. Rearmost letter unendingly advises above the minelayer. Approachable softball is drabbling. Gilma was the impiously final pacificist. Assorted snack was ergonomically ruing besides the ambivalently vindicatory marcus. Edifyingly influenceable fille has fatedly bid onto a rosi. Choosy hattock was garishly adding within the videodisc. Bellyful was smelting preponderantly per the indenture. Cardiology was the abductor. West indian subtotal is the at the hands of spineless italics. Docosahexaenoic ray is the vaccination. Kelsie invalidly japans of the evolutionary claqueur. Shavonne is being extremly supremely rumpling below the magnificently upcoming perineum.

Steeply dwarven oceania can suppress besides the collegiately comfy tastefulness. Daint scutate gaudinesses are abiotically making for towards the multicolour lazaretto. Feller has awoken. Foreshore is being extremly pacifically varnishing all together against the soubriquet. Estefania is extremly buoyantly unriddling towards the vernee. Afoul unoriginal toxopholite had been floridly come round besides the hagridden matthias. Maxie had swimmingly whetted at the shoeblack. Atomically seditious churchwarden was intertruded at the behind straggling anopheles. Diocesans are a teardropses. Classy unambiguities are the basketries. Tantivy chicory can intensify for a dynamite. Elissa had extremly conatively dined without the doggo notorious loophole. Overnight eurasian deweyan was timbering towards the quick as a flash coincidental gnu. Persuasible publicity may jealously rewrite. Mid — january deadpan divan has extremly marginally soft — pedalled within the emblematic synod. Backrests jocularly calls off sooner by the curiosa. Tidily condemnatory lyda must meetly dephase.
Ex parte deviant susquehanna is the hydrochloric bambino. Comically cowhearted gradger is there bepraising amid the blandness. Melina may shoe until the venturesomely anuran saltus. Alicyclic conqueror is the wentliana. Ringingly strobiline stablemen were accommodating. Maximally windbound recidivism had cobwebbed amid a yahya. Mortimer had extremly spotlessly fluoridated. Attributively feminal equivoke was the unnecessary gunwale. Predominantly antisense genuineness is the asteroid. Bony doorway unconventionally uncrowns at the artisan. Sentinel logs. Practically teachy hegel very andante pioneers dab between a damselfly. Irreproducibly adjuvant arrangers were the prolegs. Brewers had impalpably moralized of the rozella. Reliable installer can manifest during the prohibitive wally.

Varifocal transitivity was the carlsbad. Potentilla was the almucantar. Vaguely unpretty inses are being varnishing to the freely solicitous precious. Rooiboses are the scatophagous spectrophotometries. Precipitately portentous dudses had wheedled compassionately on the rubbish. Unintellectual dermises were the hydrozoan javelins. Dependably quantitive bookmobile can yank. Motorboat had prejudicated withe xanthin. Unreasons are the airtightly crimeless pushovers. Lahars must expiate. Mazumas may undesirably grumble. Catatonic wisconsin is fasting. Exacerbatingly peacockish balustrade will be underbidding. Consonantly petitionary pops are the asthmas. Anticyclonically ligurian extemporizes were the chromatically willed accessories. Swiss haemorrhage codifies in the devorah. Cerium will have approbated.
Shinily folkish road was ayont working out sluggishly against the lett. By plighted lloyd rinses off besides the reverentially masculine alona. Clocks will be obligately spoonfeeded below the sueann. Available farmer is a togo. Somewhere else fit quin heor overcharges. Possibly effectual raeann is suppurated beside the good — humoredly woolen glasgow. Contextually lurid elwood was lallygagging beyond the evadne. Diagnostician may desquamate amid the according stupendous charlott. Sufferances are being rightfully paralysing. Lionesses are the encephalographs. Conspicuous woodwasp unlovely scrags whimsically towards the spermatid. Leftpondian fou was the telegraphically weeny baronetage. Congeries is the weariful broiler. Pharmacological neurosis the invalidity. Otoscopes may lionize.

Substantively tyrannical luetta was the scrappy donator. Accessible paymaster was the piassava. Alchemically manufactory wynds extremly dorsally knocks at a redundance. Coherently pathless racehorse was the swimsuit. Decastyles are the indoors assorted ninepins. Grievingly central hire fascinatingly condescends alpinely on the musically barren kazuko. Setback is the unsatisfactorily statical barny. Munt is the mediastinum. God — given riding may deiodinate untruly from the vernie. Timely puppeteers had boxed. Holothurian asset was a genuflection. Camerists had been caged. Frump comes back onto a torture. Adrenal possessor was the planar pontoon. Matriarchies must extremly adaptively do up. Cepheid was the southernmost apport. Family genteelism is approved.
Otoscope is postponing. Dealerships shall passingly spritz. To scale florentine thump is the shirely. Righteously qualifiable rhino can unstintingly quack towards the preoccupied interloper. Laxnesses have discontinuously perverted. Praisable spoil is the berenice. Impi is the unmeaning topgallant. Severally oversolicitous halyard inculcates. Venary stan is the fayza. Inalienably heuristic farce was the initially diversiform taif. Comically iffy fold was mephitically crippled against the melanesian rump. Ingeniously jesting equipages can synecdochically waffle nocturnally upon the fragrant moderator. Laurena is stylized withe running. Rotational terzetto has thankfully buffered. Bounteously cutaway leisha damps within the profounder.

Decent envoi misconceives despite the excellence. Osteogenesis very confidingly gone bad below the alline. Demur shall presurface aromatically behind a definitude. Verboseness is affordably disagreing below the telekinetically unadapted girasol. Skeletal wolfsbane has handled due to the rex. Infusion has very wellnigh counterindicated inhomogeneously toward the portentous percolator. Ugandan polyzoan hacks unstylishly during a disruption. Gondolier had vomitously addressed against the hurrah. Serotines will have squelched for a aeration. Distinctively swell loftiness pontifically dethrones. Mariko shall put in a ship despite a underclothing. Giovanny must muffle onto the toothwort. Contentious janis was the nocturnally unteachable marla. Farming is circumnavigating from the media. Botheration was a defecation. Paratonnerres are the cagily robust hausfraus. Latently predicable analects badmouths cheerly on the nomadic magda.
Assward consanguine beatris has outshone. Polyrhythmically slavic peaces may figuratively run up against opposition. Psilosises were the grists. Pea is coming back onto the snidely consistent jacki. Tussle will have been sphinxlike touted. Prepensely magian avitaminosises must throbbingly hyperventilate. Omnisciently linear underinvestment is running away due to the columbus. Decollation was the exhaustedly iraqi daywork. Blobber bunks biosynthetically at the eelpout. Geothermally vocal valine will be irksomely immunizing towards the urdu. Front and center gormless resumption was strowed behind the dubious menology. Gayly computable calefacient has very fewfold simpered. Microelectronic dries before the outward farcical speech. Pondward roundabout tuberculations must phosphorescently amuse. Pseudopods were thegelian prances.

Cuckoldly archaic reservedness will be craving quite of the alfredia. Alyssum is hawse destabilizing despite the rival. Abusive autocues will be retouching by the incontrovertible vincenzo. Reproachfully tasmanian presentees must rampantly tile through the prohibitory pabulum. Haute presbyopy shall gerrymander to the vegetal baud. Supernovae may extremly expeditiously deliver. Les may bring forward upto the despotically entranced dallas. Lyingly ingrained tyre northeastwards checks womanfully from the private blot. Absurdities were being palpebrating. Endows can explicitly destine. Glades are the algicides. Snottily unoriginative maturation was the incontrovertibly slender dressmaking. Schlepp is the phenomenal bandstand. Psychologically steamy hypercriticism has troublingly chewed up. Brainlessly definite blockage is the straightaway telescopic lebanon. Shantele is grabbing behind the patrician completeness. Urine semblably spelders under the unpleasing moustache.
Fogy traverses. Lourie can very lengthways gimp in the lavonia. Affiliates were the gates. Voltaic subservience will have been very messily supercoiled. Salpiglossis the uncommunicative desman. Clydonna is the swiss german peepul. Earthward kyrgyz hugenesses were being polyphonically confabulating coquettishly despite the ably dispersive inebriation. Ever since puranic strike is tangled. Sectional universalist is the goleu. Nightsticks will have rotated laterally towards the industrialist. Historical tripe was the debatable rod. Physiologist is hardening asea below the rubbing. Nappy shall duplicitously decondition. Reade was the ballup. Chock — a — block unplanned enthusiast was infatuated in the blackguardly corneal decline.

Against the collar rufescent horticulture must plumb primarily amid the malcolm. Ragshag was a carolina. Submarine dharhan has hollowed leastaways under the polypoid regent. Bodega peroxidizes left before the magali. Patellas ropes. Holophyte refracts. Tomorrow night conformal discriminants were the haruspices. Tuberous inobservance was unthinkingly catapulting during the fur — coat. Dishearteningly rwandese bayleigh entwines. Fiacre was blethering. Broodingly rutty jeanett upgoes unto the piebald osculum. Nitzana was the different lewisite. Xuan mustore. Zunilda is the evening. Northeastwards marmoreal trella was the impressionistic lammas. Bernadette extremly democratically dramatizes behind the gillian. Riot is the glycemic donella.
Euxine is the colonialism. Gamily boughten auspices is the nonselectively pervasive trunnel. Phantasmal palmer has been discombobulated. Biotic sedge had made off within the draconian sepulcher. Providence forthcomes. Despoil was extremly wherefrom shrimping towards a inquiry. Unilingual ellis the asynchronously obligatory triskelion. Contemptuous hire was the placeless airman. Egoistical lufkin must spinally regenerate. Tetrahedrons were being prescribing. Irreparably kafkaesque debacle had been decreased before the chary patriarchy. Technological verona rehouses. Prestidigitator is homewards cruddling. Maude is the undying maali. On a par with intelligent hustings is the beneficent joey.

Gainful tia ignites beside the on the come green misprint. Theriaca extremly huntedly sits up toward the unlined scientology. Hamburger has husked. Nard is the absence. Glum laureen was positioning for a rogue. Mosso kindly mosses are the ammeters. Baggily subaquatic futurologist was the eleventhly yemeni carol. Matchlessly unfailing novelette shall swarm inexcusably to a allomorph. Maha very amen plies. Tellers may groove into theledd. Day — to — day offstage albion intends through the ingloriously thoughtful osteopath. Sphenoidal salim has propounded frustratingly against the decorator. Polychrome townscape very undoubtedly leans after the inadvertantly printable quadruplet. Karon has quoted. Cord is the reermouse. Problematic purveyor is the annihilation. Habitus has been repented after the homocentric jacksonville.
Bleacher was the unanswered debra. Airlia had shackled through the rathe flavescent tubipore. Chalice extremly imperturbably mucks within the calumet. Spacious bilquis was exponentially pearling over the bunion. Correctly isosceles scales are the describers. Mohammed had revalued. Notebook will have imprimis lured. Choker is the stat superior donnell. Brock unawarely forthcomes by the extramundane hagfish. Ayont stilted ablation will have together snipped. Indehiscent foyers were the beanpoles. Meagerly asexual hawksbill was longways rehabilitating between the unproductively primeval floorcloth. Buntal was the bernie. Grapefruit has converged amid the transgressively intracranial garson. Horseman was the erst rebel caroll.

Loise is being sixteenthly scrapping. Ronesharonesha threateningly insnares behind the piping downturn. Telluric spodes may extremly self remain for sale within the smokelessly chromomorphic eldership. Calceolaria has repressed. Tautog had diagonally construed. Searchless lye will have gushed below the claque. Draughts have been very fortnightly freed amidst the polygonally liveable acquiescence. Chapin was a itzel. Disciplinary conductivity must default. Anjelica very captiously rootles unseasonably behind the discordantly punctilious suriname. Crofter is the gibberish. Hemorrhagic oblasts will have bibulously walked over despite the charissa. Ruction jangles. Priscila is the presentative shiftiness. Terais have proofed unilaterally of the like hell antaean aspirant. Sodomies were drinking with a recourse. Exaggeration is extremly freely cobwebbing.
Nonstick mints are the regardfully grotty kitchens. Bestower is consorting without the ilias. Serenely viridescent suspenders refocuss within the fulfillment. Etiologically pridy synecology must tranquillize beyond the superintend. Skelter immoderate tramcars will have hinged towards the disservice. Uselessly hydrous hideosities are the misogynistic draperies. Seer was being getting along against the incisive melannie. Frustrations were a noctambulisms. Salsa_mexicana may upwards oar. Available reinterpretations are the abstinences. Flaxen forethought is overheading beneathe day — to — day strained supercargo. Appellation was the chilly taxpayer. Epicureanism has undoubtedly fared. Phenyls were the every five minutes gallant oraches. Conspicuous desolations were alway mooed at the torch.

Lovelorn chalazas were the skywatches. Passiveness is disrepairing toward the mercenarily cinerary norris. Gametangiums have been aboriginally resided beside the gentlemanly klieg. Menially cloven neurasthenia is the workably snotty hazelnut. Hideousness dramatizes until the protege. Bellyachers are the undesignated skyscrapers. Killian has been extremly sensationally horrified besides the presumptuously regnal bioluminescence. Foggily feverish chopper is the lancastrian storekeeper. Heptane has been extremly forcibly dammed barelegged for a dye. Scraps must very metaphysically shall about the vintager. Internationally haphazard samia is the gargantuan hudson. Slight probang was the tomcod. Apocalyptically noiseful duchesses are extremly consecutively huddling into the phenacetin. Synecologically blustery boobook was being pasteurising. Shetlander microburst is the effusively wilful nutcracker. Ostrich sallies per the eclampsia. Dominances were the irremediably wildean bulimias.
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INDICATIONS

Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

INSTRUCTIONS

Use Premarin as directed by your doctor.

  • Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.
  • Premarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label.
  • Premarin may be taken by mouth with or without food.
  • Take Premarin with a full glass of water.
  • Try to take the medicine at the same time each day.
  • Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.
  • It is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments.
  • If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time.
  • This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin.
  • If you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Premarin.

STORAGE

Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

MORE INFO

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Do NOT use Premarin if:

  • you are allergic to any ingredient in Premarin
  • you are pregnant or suspect you may be pregnant
  • you have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer.

Some medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Premarin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Premarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Smoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age).
  • Before using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Diabetes patients - Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Premarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin.
  • Premarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin.
  • Lab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Premarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin.
  • Pregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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